Non-GLP Discovery Toxicology


The early identification of toxicity in non-GLP in vivo safety studies allows better utilization of resources in more costly and time consuming regulatory toxicology studies. In addition, the information from the discovery safety experiments triggers early mechanistic efforts to understand the nature of the toxicity and to select the most viable development candidates or to make an early no-go decision for the target.

Non-GLP Discovery Toxicology and Rodent Clinical Pathology Services:

Test Agent Administration

  • Oral Gavage
  • Intravenous
  • Intra-peritoneal
  • Intra-tumor
  • Intra-tracheal
  • Intra-nasal
  • Subcutaneous
  • In diet
  • Other

Body Weight Measurements

Serum and Urine Clinical Chemistries

Hematological Analysis of Peripheral Blood

Immuno-phenotyping of Peripheral Blood and Tissues by Fluorescence-activated call sorting (FACS)

Tissue Collection and Processing for Histological Analysis

Phenotypic Characterization of Genetically Modified Mice for Target Liability Assessment

Toxicity Evaluation in Knock-Out Mouse Models

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