SERVICES

The immune system plays a pivotal role in the pathogenesis of many common diseases, including autoimmune and infectious disease, cancer, atherosclerosis and allergies. Along with offering a broad spectrum of disease models and bioassays focused in Immunology and Inflammation, our multidisciplinary scientific team custom-designs each study to expand the capacity of your drug discovery research needs. Interpretive data analysis and a complete raw data set are provided in the final report to accelerate your decision making process.

The Invivotek Immunology and Inflammation Program offers the following models and bioassays:

Animal Disease Models

• Antigen-induced Arthritis for Rheumatoid Arthritis
• Collagen-Induced Arthritis for Rheumatoid Arthritis
• Monoclonal Antibody Induced Arthritis for Rheumatoid Arthritis
• Experimental Autoimmune Encephalitis for Multiple Sclerosis
• Allergen-induced Pulmonary Inflammation for Asthma
• Lipopolysaccharides (LPS)-induced Airway Inflammation
• Acute lung injury model (LPS-induced)
• DSS-induced Colitis for Ulcerative Colitis
• TNBS-induced Colitis for Crohn’s Disease
• Allergic Dermatitis (DNFB or Oxazolone induced)

Non-Disease In vivo Bioassays

• Non-lethal Endotoxemia with LPS
• Antigen-dependent In Vivo T-cell Proliferation by BrdU uptake
• OVA-stimulated In Vivo Antibody Production (IgG1, IgG2a, IgG2b)
• KLH-stimulated In Vivo Antibody Production (IgM, IgG)
• Delayed Type Hypersensitivity by mBSA or KLH with adjuvant
• Delayed Type Hypersensitivity by SRBC
• Monocyte or Neutrophil Infiltration induced by Thioglycollate or Zymosan or Curdlan or Tripsin
• Cutaneous Wound Healing

Ex vivo Bioassays

• Serum and Tissue Cytokine Profiling in animal disease models
• FACS Analysis of Lymphoid Organs and Tissue Infiltrates
• Hematology Five Part Differential Cell Count
• Proliferative responses of T and B cells in vitro
• In vitro cytokine production assays
• T cell differentiation assay